Cutaneous melanoma (CM), recognized as the most aggressive form of skin cancer, presents a significant global health burden. Acral lentiginous melanoma (ALM), a distinct subtype of CM primarily affecting individuals with darker skin tones, poses diagnostic challenges due to its diverse clinical presentations. While ALM is commonly characterized by flat, pigmented lesions, rare reports have documented its manifestation as a nodular growth. This case series includes four Filipino cases of nodular ALM, allowing for a comprehensive analysis and comparison with typical ALM presentations. Additionally, two case reports of ALM progressing to nodular growth are presented, further highlighting the clinical variation within this subtype. The series underscores the importance of accurate diagnosis through histopathological examination and specific stains, enabling differentiation from other conditions. Treatment strategies involve wide local excision or amputation, with additional therapeutic options for advanced cases. Improved awareness among healthcare professionals regarding nodular presentations of ALM is crucial for early detection and optimal management. Further research is needed to enhance our understanding and refine management strategies for this challenging subtype of melanoma.