Journal of Clinical & Medical Case Reports
Case Report
Metformin-Induced Irritable Bowel Syndrome–Like Symptom
Sibi Das*
Department of Medicine NC Medical College, Israna, Panipat, Haryana, India
Address for Correspondence:Dr. Sibi Das, Department of Medicine NC Medical College, Israna,
Panipat, Haryana, India. E-mail Id: sdsilvanose@gmail.com
Submission: 03 February, 2026
Accepted:13 March, 2026
Published:16 March, 2026
Copyright: © 2026 Das S, et al. This is an open access article
distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Keywords:Metformin intolerance; irritable bowel syndrome; Type 2
diabetes mellitus; Dapagliflozin; SGLT2 inhibitors
Abstract
Metformin is the first-line pharmacological therapy for type 2
diabetes mellitus (T2DM). Although gastrointestinal (GI) adverse
effects are common, persistent symptoms resembling irritable bowel
syndrome (IBS) are less frequently reported. We present the case of
a 56-year-old male with T2DM who developed metformin-induced
IBS-like symptoms (IBS -D) characterized by abdominal cramping,
bloating, and postprandial diarrhoea triggered by specific dietary
factors. Symptoms significantly worsened following metformin dose
escalation from 500 mg to 750 mg daily. Laboratory evaluation
revealed adequate glycemic control with fasting blood glucose of
140 mg/dL and HbA1c of 6.5%. After discontinuation of metformin and
initiation of dapagliflozin 10 mg daily along with dietary modification,
gastrointestinal symptoms markedly improved while glycemic control
remained stable. This case highlights the importance of recognizing
metformin-induced IBS-like symptoms and considering alternative
antidiabetic therapies when intolerance occurs.
