Journal of Nutrition & Health
Research Article
Evaluation of Acute and Sustained Cognitive Effects of a Grape and Blueberry Polyphenol-Rich Extract in Healthy 7-12 Years Old Children: A Home-Based, Real-World Consumer Study
Ilona Gille, Emmanuelle Arnaud*, Maïté Jeanroy, Benoit Lemaire, David Gaudout
Activ’Inside, Beychac-et-Caillau, France
*Address for Correspondence:Emmanuelle Arnaud, Activ’Inside, Beychac-et-Caillau, France,
Email: e.arnaud@activinside.com
Submission: 03 February, 2026
Accepted:10 March, 2026
Published: 14 March, 2026
Copyright: © 2026 Gille I, et al. This is an open access article
distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction
in any medium, provided the original work is properly cited.
Keywords:Cognition; Executive function; Polyphenols; Children; Open study; Memophenol™
Abstract
Background: Executive functions such as attention, working memory, and emotional regulation undergo rapid development during school age, a period marked by increasing academic demands. This creates a specific need to support cognitive efficiency in children, whose regulatory capacities are still maturing. Polyphenol-rich nutritional interventions have previously shown benefits on executive processes in adults, but evidence
in younger children remains limited, justifying investigation in this age group.
Objectives: This open trial aimed to evaluate both the acute and chronic effects of daily supplementation with Memophenol™ on cognitive performances in children under real- world conditions.
Methods: A 28-day medically supervised real-world open trial was conducted in 41 healthy children (aged 7–12 years) from Singapore. Participants daily consumed one red-berry flavored stick powder containing a polyphenols-rich extract from grape and blueberry (150 mg of Memophenol™), each morning with breakfast. Children’s cognitive performance was assessed using the CogniFit Kids digital platform at four points (D0, D0+2h, D14, D28). Parents assessed their child’s behavioral and executive functions using an adapted version of the validated BRIEF-2 questionnaire (D0, D14, D28), followed by a satisfaction survey at D28.
Results: Children’s cognitive performance improved significantly by +9.5% 2 hours after Memophenol™ intake compared to baseline, as well as by +13.9% after 14 days, and +17.1% after 28 days of supplementation (p < 0.001). Executive function, as assessed by the BRIEF-2 Global Executive Composite (GEC), decreased by –8.3% and –12.9%, respectively after 14 and 28 days of supplementation (p < 0.001), reflecting better overall executive control. In addition, improvements in the Behavior Regulation (–11.5%), Emotion Regulation (–14.4%), and Cognitive Regulation (–12.8%) indices were observed after 28 days. Parents reported noticeable improvements in attention (63%) and overall efficacy (66%). The formulation was well tolerated.
Conclusions: These preliminary findings suggest that daily intake of 150 mg Memophenol™ may improve cognitive functions in children, with both acute and cumulative benefits after 28 days, observed in a real-world setting. The formulation demonstrated good safety and acceptability, supporting its potential as a natural strategy to enhance cognitive functions and behavioral regulation in school-aged children. These results highlight the potential of polyphenol supplementation to support learning performance and behavioral regulation in children under high academic demand. However, given the absence of a control group and the potential for expectancy and learning effects, these results should be interpreted with caution. Further randomized, controlled, and blinded studies are warranted to confirm these promising effects.
Objectives: This open trial aimed to evaluate both the acute and chronic effects of daily supplementation with Memophenol™ on cognitive performances in children under real- world conditions.
Methods: A 28-day medically supervised real-world open trial was conducted in 41 healthy children (aged 7–12 years) from Singapore. Participants daily consumed one red-berry flavored stick powder containing a polyphenols-rich extract from grape and blueberry (150 mg of Memophenol™), each morning with breakfast. Children’s cognitive performance was assessed using the CogniFit Kids digital platform at four points (D0, D0+2h, D14, D28). Parents assessed their child’s behavioral and executive functions using an adapted version of the validated BRIEF-2 questionnaire (D0, D14, D28), followed by a satisfaction survey at D28.
Results: Children’s cognitive performance improved significantly by +9.5% 2 hours after Memophenol™ intake compared to baseline, as well as by +13.9% after 14 days, and +17.1% after 28 days of supplementation (p < 0.001). Executive function, as assessed by the BRIEF-2 Global Executive Composite (GEC), decreased by –8.3% and –12.9%, respectively after 14 and 28 days of supplementation (p < 0.001), reflecting better overall executive control. In addition, improvements in the Behavior Regulation (–11.5%), Emotion Regulation (–14.4%), and Cognitive Regulation (–12.8%) indices were observed after 28 days. Parents reported noticeable improvements in attention (63%) and overall efficacy (66%). The formulation was well tolerated.
Conclusions: These preliminary findings suggest that daily intake of 150 mg Memophenol™ may improve cognitive functions in children, with both acute and cumulative benefits after 28 days, observed in a real-world setting. The formulation demonstrated good safety and acceptability, supporting its potential as a natural strategy to enhance cognitive functions and behavioral regulation in school-aged children. These results highlight the potential of polyphenol supplementation to support learning performance and behavioral regulation in children under high academic demand. However, given the absence of a control group and the potential for expectancy and learning effects, these results should be interpreted with caution. Further randomized, controlled, and blinded studies are warranted to confirm these promising effects.