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Research Article
Aerosol Delivery Enhances Percutaneous Permeability of Epidermal Growth Factor and Thioredoxin
Hai Tian1, Atsushi Fukunaga2*, Junji Yodoi3 and Chikako Nishigori2
- 1Redox Bio Science Incorporated, Kyoto, Japan
- 2Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan
- 3Department of Biological Response, Institute for Virus Research, Kyoto University, Kyoto, Japan
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
*Address for Correspondence: Atsushi Fukunaga, Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho Chuo-ku Kobe, 650-0017, Japan, Tel: 81-78-382-6138; Fax: 81-78-382-6149; E-mail: atsushi@med.kobe-u.ac.jp
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Citation: Tian H, Fukunaga A, Yodoi J, Nishigori C. Aerosol Delivery Enhances Percutaneous Permeability of Epidermal Growth Factor and Thioredoxin. J Clin Investigat Dermatol. 2016;4(1): 5.
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year. Copyright © 2016 Tian H, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year. Journal of Clinical & Investigative Dermatology | ISSN: 2373-1044 | Volume: 4, Issue: 1
Submission: 01 December 2015| Accepted: 23 January 2016 | Published: 29 January 2016
Submission: 01 December 2015| Accepted: 23 January 2016 | Published: 29 January 2016
Abstract
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Introduction
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Materials and Methods
Nano-spray instrument (NSI)
Figure 1:The nano-spray instrument is nanometer atomization facial beautification instrument, which is adopted with the ultrasonic vibration and atomization technology. It can atomize the water/lotion (without oil) into ultrafine particles with diameter of 3-5 µm by vibrating millions times per second. The velocity of the particles is almost 4.1-4.2 m/s when they are expelled from the nozzle exit. The flow rate of the mist was 1 ml/min.
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Results
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Results
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Conclusion
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Acknowledgements
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
Discusion
In order to determine if there is a seasonal pattern to GA appearance, a retrospective analysis of histopathological and clinical reports was done at the Ackerman Academy of Dermatopathology. Using the computer database, we included 753 total cases diagnosed at the Ackerman Academy from 2008-2011. Specimens were obtained from 574 females and 179 males with an average age 53.7±16.7 years. A total of 500,432 cases were signed out during the study period. The percentage of GA cases diagnosed in every month was calculated by taking into account the number of diagnosed cases during that month to exclude variation of specimen number throughout the year.
References
- Leppard B, Black MM (1972) Disseminated granuloma annulare. A variant in which the lesions involve the sun-exposed areas. Trans St Johns Hosp Dermatol Soc 58: 186-190.
- McLelland J, Young S, Marks JM, Lawrence CM (1991) Seasonally recurrent granuloma annulare of the elbows. Clin Exp Dermatol 16: 129-130.
- Uenotsuchi T, Imayama S, Furue M (1999) Seasonally recurrent granuloma annulare on sun-exposed areas. Br J Dermatol 141: 367.
- Dabski K, Winkelmann RK (1989) Generalized granuloma annulare: clinical and laboratory findings in 100 patients. J Am Acad Dermatol 20: 39-47.
- Ragaz A, Ackerman AB (1979) Is actinic granuloma a specific condition? Am J Dermatopathol 1: 43-50.
- Browne F, Turner D, and Goulden V (2011) Psoralen and ultraviolet A in the treatment of granuloma annulare. Photodermatol Photoimmunol Photomed 27: 81-84.