Journal of Vaccine & Immunotechnology
Study of Genetic Mutations in Gene ZAP70 in Inducate ZAP70-Related Severe Combined Immuno Deficiency Syndrome
Department of Medical Genetics, Molecular Medicine Genetics Harvard University, Iran
*Address for Correspondence: Shahin Asadi, Department of Medical Genetics, Molecular Medicine Genetics Harvard University, Director of the Division of Medical Genetics and Molecular Research, Division of Medical Genetics and Molecular Pathology Research, Massachusetts, Iran, E-mail: firstname.lastname@example.org
Submission: 02 March, 2019; Accepted: 03 April, 2019; Published: 05 April, 2019
Copyright: © 2019 Asadi S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ZAP70-SCID syndrome is a hereditary genetic disorder that damages the immune system. Children with SCID have virtually no immune system against bacterial, viral, and fungal infections. SCID is a group of very rare, life-threatening diseases that are present at birth. The disease causes the child to have very little or no immune system. As a result, the child’s body is unable to fight off infections. This disease process is also known as the “boy in the bubble” syndrome because living in the normal environment can prove fatal to these children.
Children with this rare, inherited disease become very ill with illnesses such as pneumonia, meningitis, and chickenpox and can die within the first year of their life. With new advances in treatments, however, children with SCID can be successfully treated.
ZAP70-SCID syndrome is caused by the mutation of the ZAP70 gene, which is based on the long arm of chromosome number 2 as 2q11.2.
ZAP70-SCID syndrome; ZAP70 gene; Immune system
Discussion and Conclusion
ZAP70-SCID syndrome is a hereditary genetic disorder that damages the immune system. Children with SCID have virtually no immune system against bacterial, viral, and fungal infections. ZAP70- SCID syndrome is caused by the mutation of the ZAP70 gene, which is based on the long arm of chromosome number 2 as 2q11.2. There is no standard treatment for this syndrome, and all clinical interventions are designed to reduce the suffering of the sufferers.
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