Diabetic Cystopathy

Diabetic cystopathy (DCP) is the most common complications in diabetes mellitus, prone to diabetic patients. The Symptoms of DCP are under-activity of the detrusor muscle and increased post-voiding residual volume, which would induce severe urinary tract infection, vesico-ureter reflux, hydronephrosis, and even uremia and renal failure .
The underactivity of DCP has the disturbance of spontaneous contractility, caused by reduced suburothelial ICCs in DCP patients.

imagesThe c-KIT protein is a specific marker on the cell membrane of ICCs, which is encoded by the c-KIT proto-oncogene. Activation of the c-KIT gene can modulate cell growth, differentiation, and phenotype, while mutation of c-KIT leads to ICCs absent . The stem cell leukemia gene (SCL) is a tissuespecific transcription factor of the basic helix-loop-helix family, functions in hematopoietic development, is normally expressed in pluripotent hematopoietic precursors, and is downregulated in maturing cells. SCL induces c-KIT expression in chromatin.

This c-KIT regulation involves proper activation of the c-KIT promoter by the SCL protein, which coordinates SCL complex binding on the promoter sequence to activate c-KIT transcription. For the transfer of genetic material to target tissue, the use of intravesical lentiviral vector-mediated gene delivery to bladder cells has been shown to be efficacious and safe for the treatment of bladder cancers. Treatment with medicine. Sometimes it is treated with special urinating (voiding) techniques, surgery, or other methods.

The effects of aging on renal function and the lower urinary tract can be exacerbated by superimposed chronic disease, particularly diabetes mellitus. Diabetic nephropathy, a life-threatening condition, has received considerable attention. Diabetic cystopathy (DC) has received less, although it is a chronic complication that affects day-to-day life, predisposes individuals to urinary tract infections (UTIs), potentiates renal complications, and poses obstacles to optimum health.

Journal of Urology & Nephrology

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