Journal of Pharmaceutics & Pharmacology
Research article
Hypoglycaemic Risk and Antihyperglycaemic activity of “Diabète free” and “Pancréas free”, an Anti-diabetic Combination from an Ivorian Traditional Practitioner
Etienne EK, Josué YK, Adebo AY, Awa S, GenevièveIrié NG and Giséle KS*
Department of Pharmacology, Faculty of biological and pharmaceutical sciences, University of Félix Houphouët-Boigny,
Abidjan - Côte d’Ivoire
Address for Correspondence:EFFO Kouakou Etienne, Department of Pharmacology, Faculty of biological and pharmaceutical sciences, University of Félix Houphouët-Boigny, Abidjan - Côte d’Ivoire, E-mail Id:
eff oet@yahoo.fr
Submission:15 September 2024
Accepted:12 October 2024
Published:15 October 2024
Copyright: © 2024Etienne EK, et al. This is an open access article
distributed under the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.
Keywords:Diabetes; Diabète Free; Pancréa Free; Hypoglycaemic;
Antihyperglycaemic
Abstract
Diabetes remains a public health issue for which traditional
medicine offers a therapeutic response. The aim of this study was
to assess the hypoglycaemic risk and antihyperglycaemic activity
of ‘Diabète Free’ and ‘Pancréa Free’, remedies used by an Ivorian
traditional practitioner to treat diabetes.
For the hypoglycaemic risk, 4 groups of 6 rats per group were successively given ‘Diabète Free’ and ‘Pancréa Free’ by oral route at respective doses of 7mg/kg and 4.5mg/kg, 14mg/kg and 9mg/kg, 28mg/kg and 18mg/kg, or NaCl. To evaluate the antihyperglycaemic activity, 5 groups of 6 rats per group were successively treated with ‘Diabète Free’ and ‘Pancréa Free’ by oral route at respective doses of 7mg/kg and 4.5mg/kg, or 14mg/kg and 9mg/kg, or 28mg/kg and 18mg/kg, or NaCl, or glibenclamide at 10mg/kg. An oral glucose overload at a dose of 10g/kg was administered 30 min later. In each case, blood glucose levels were monitored every hour for 4 hours using blood from rats’ tailvein.
The ‘Diabète Free’ and ‘Pancréa Free’ combination showed no hypoglycaemic risk. The combination at doses of 14mg/kg and 9mg/ kg, as well as 28mg/kg and 18mg/kg, showed a signifi cant reduction in orally induced hyperglycaemia from the 1st hour without causing hypoglycaemia.
The combination of ‘Diabète Free’ and ‘Pancréa Free’ is thought to have antihyperglycaemic activity without anyrisk of hypoglycaemia. This remedy combination could be an alternative to conventional antidiabetic treatments.
For the hypoglycaemic risk, 4 groups of 6 rats per group were successively given ‘Diabète Free’ and ‘Pancréa Free’ by oral route at respective doses of 7mg/kg and 4.5mg/kg, 14mg/kg and 9mg/kg, 28mg/kg and 18mg/kg, or NaCl. To evaluate the antihyperglycaemic activity, 5 groups of 6 rats per group were successively treated with ‘Diabète Free’ and ‘Pancréa Free’ by oral route at respective doses of 7mg/kg and 4.5mg/kg, or 14mg/kg and 9mg/kg, or 28mg/kg and 18mg/kg, or NaCl, or glibenclamide at 10mg/kg. An oral glucose overload at a dose of 10g/kg was administered 30 min later. In each case, blood glucose levels were monitored every hour for 4 hours using blood from rats’ tailvein.
The ‘Diabète Free’ and ‘Pancréa Free’ combination showed no hypoglycaemic risk. The combination at doses of 14mg/kg and 9mg/ kg, as well as 28mg/kg and 18mg/kg, showed a signifi cant reduction in orally induced hyperglycaemia from the 1st hour without causing hypoglycaemia.
The combination of ‘Diabète Free’ and ‘Pancréa Free’ is thought to have antihyperglycaemic activity without anyrisk of hypoglycaemia. This remedy combination could be an alternative to conventional antidiabetic treatments.