Journal of Clinical and Investigative Dermatology
Research Article
Evaluation of a Grape Extract and Coenzyme Q10-Based Nutricosmetic Formula on Cellulite-Related Parameters
Emmanuelle Arnaud, Ilona Gille, Maïté Jeanroy, Benoit Lemaire and David Gaudout
Activ’Inside, Beychac-et-Caillau, France
*Address for Correspondence: Emmanuelle Arnaud, Activ’Inside, Beychac-et-Caillau, France,
Email: e.arnaud@activinside.com
Submission:28 November, 2025
Accepted:18 December, 2025
Published:20 December, 2025
Copyright: © 2025 Arnaud E, et al. This is an open access article
distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Keywords: Nutricosmetic; Cellulite; Long-term efficacy; Grape extract;
Coenzyme Q10
Abstract
Background: Cellulite is a common cosmetic concern in women,
associated with alterations in microcirculation, adipocyte hypertrophy,
and connective tissue remodeling. Nutricosmetic formulations based
on natural extracts may represent a non-invasive option to support
long-term skin appearance.
Objectives: To evaluate the effects of a patented oral formulation (Celluvine™) containing grape extract and coenzyme Q10 on celluliterelated parameters in women under real-world conditions.
Methods: This real-world study included women aged 30-50 years with a body mass index between 25 and 30 and visible cellulite. Participants consumed one capsule per day (283 mg) for two months, followed by a one-month follow-up without supplementation. Selfassessed parameters (orange peel appearance, water retention, physical complexes, self-confidence, body well-being, sensation of lightness) were rated on a 0-10 scale at baseline, 1 month, 2 months, and after follow-up. Objective measurements (weight, body fat, body circumferences) were performed at baseline and 2 months.
Results: Forty participants completed the protocol. After two months, significant improvements were reported in orange peel appearance (-22%), water retention (-25%), and physical complexes (-22%). Self-confidence (+56%), body well-being (+61%), and sensation of lightness (+98%) increased in parallel. Objective measures confirmed reductions in body weight (mean -2.3 kg), body fat (mean -12.4%), and waist (-5.9 cm), hips (-4.9 cm), and thighs (-4.4 cm) circumference. No adverse effects were reported. Benefits were maintained after the follow-up period.
Conclusions: Daily intake of the formulation was safe, well tolerated, and associated with measurable improvements in celluliterelated parameters and well-being. Larger placebo-controlled trials are needed to confirm these findings.
Objectives: To evaluate the effects of a patented oral formulation (Celluvine™) containing grape extract and coenzyme Q10 on celluliterelated parameters in women under real-world conditions.
Methods: This real-world study included women aged 30-50 years with a body mass index between 25 and 30 and visible cellulite. Participants consumed one capsule per day (283 mg) for two months, followed by a one-month follow-up without supplementation. Selfassessed parameters (orange peel appearance, water retention, physical complexes, self-confidence, body well-being, sensation of lightness) were rated on a 0-10 scale at baseline, 1 month, 2 months, and after follow-up. Objective measurements (weight, body fat, body circumferences) were performed at baseline and 2 months.
Results: Forty participants completed the protocol. After two months, significant improvements were reported in orange peel appearance (-22%), water retention (-25%), and physical complexes (-22%). Self-confidence (+56%), body well-being (+61%), and sensation of lightness (+98%) increased in parallel. Objective measures confirmed reductions in body weight (mean -2.3 kg), body fat (mean -12.4%), and waist (-5.9 cm), hips (-4.9 cm), and thighs (-4.4 cm) circumference. No adverse effects were reported. Benefits were maintained after the follow-up period.
Conclusions: Daily intake of the formulation was safe, well tolerated, and associated with measurable improvements in celluliterelated parameters and well-being. Larger placebo-controlled trials are needed to confirm these findings.