Journal of Analytical & Molecular Techniques

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A Modern Comparative andComprehensive Experimental Biospectroscopic Study on Different Types of Infrared Spectroscopy of Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation

Alireza Heidari*

  • Faculty of Chemistry, California South University, USA
*Address for correspondence: Alireza Heidari, Faculty of Chemistry, California South University, 14731Comet St. Irvine, CA 92604, USA; E-mail: Alireza.Heidari@calsu.us
Citation: Heidari A, A Modern Comparative and Comprehensive Experimental Biospectroscopic Study on Different Types of Infrared Spectroscopy of Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. J Analyt Molecul Tech 2018;3(1): 8.
Journal of Analytical & Molecular Techniques | ISSN: 2474-1914 | Volume: 3, Issue: 1
Submission: 18 November, 2017| Accepted: 05 February, 2018 | Published: 12 February, 2018
Copyright: © 2018 Heidari A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Fourier Transform Infrared (FTIR) Spectroscopy, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) Spectroscopy, Micro-Attenuated Total Reflectance Fourier Transform Infrared (Micro-ATR-FTIR) Spectroscopy, Macro-Attenuated Total Reflectance Fourier Transform Infrared (Macro-ATR-FTIR) Spectroscopy, Two-Dimensional Infrared Correlation Spectroscopy, Linear Two-Dimensional Infrared Spectroscopy, Non-Linear Two-Dimensional Infrared Spectroscopy, Atomic Force Microscopy Based Infrared (AFM-IR) Spectroscopy, Infrared Photodissociation Spectroscopy, Infrared Correlation Table Spectroscopy, Near-Infrared Spectroscopy (NIRS), Mid-Infrared Spectroscopy (MIRS), Nuclear Resonance Vibrational Spectroscopy, Thermal Infrared Spectroscopy and Photothermal Infrared Spectroscopy. It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-15) [1-124].
It can be concluded that malignant human cancer cells and tissues have gradually and clearly transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-15) [1-124]. It should be noted that in all of the figures y-axis shows intensity and also x-axis shows energy (keV). In addition, malignant human cancer cells and tissues were exposed under white synchrotron radiation for 30 days. Furthermore, there is a shift of the spectrum in all of spectra after irradiating of synchrotron radiation that it is because of the malignant human cancer cells and tissues shrink post white synchrotron irradiation with the passage of time. Moreover, all of the figures are related to the same human cancer cells and tissues (Figures 1-15) [1-124].
JAMT-2474-1914-03-0007-fig1
Figure 1: Fourier Transform Infrared (FTIR) Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig2
Figure 2: Attenuated Total Reflectance Fourier Transform Infrared (ATRFTIR) Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig3
Figure 3: Micro-Attenuated Total Reflectance Fourier Transform Infrared (MicroATR-FTIR) Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig4
Figure 4: Micro-Attenuated Total Reflectance Fourier Transform Infrared (MicroATR-FTIR) Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig5
Figure 5: Two-Dimensional Infrared Correlation Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig6
Figure 6: Linear Two-Dimensional Infrared Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig7
Figure 7: Non-Linear Two-Dimensional Infrared Spectroscopy analysis ofmalignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig8
Figure 8: Atomic Force Microscopy Based Infrared (AFM-IR) Spectroscopyanalysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig9
Figure 9: Infrared Photodissociation Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig10
Figure 10: Infrared Correlation Table Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig11
Figure 11: Near-Infrared Spectroscopy (NIRS) analysis of malignant cancercells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig12
Figure 12: Mid-Infrared Spectroscopy (MIRS) analysis of malignant cancercells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig13
Figure 13: Nuclear Resonance Vibrational Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig14
Figure 14: Thermal Infrared Spectroscopy analysis of malignant cancer cells andtissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].
JAMT-2474-1914-03-0007-fig15
Figure 15: Photothermal Infrared Spectroscopy analysis of malignant cancercells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-124].

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  94. Heidari A (2017) “Combination of DNA/RNA ligands and linear/non-linear visible-synchrotron radiation-driven n-doped ordered mesoporous cadmium oxide (CDO) nanoparticles photocatalysts channels resulted in an interesting synergistic effect enhancing catalytic anti-cancer activity”. Enz Eng 6: 1.
  95. Heidari A (2017) “Modern approaches in designing ferritin, ferritin light chain, transferrin, beta-2 transferrin and bacterioferritin-based anti-cancer nano drugs encapsulating nanosphere as dna-binding proteins from starved cells (DPS)”. Mod Appro Drug Des 1: MADD.000504.
  96. Heidari A (2017) “Potency of human interferon β-1a and human interferon β-1b in enzymotherapy, immunotherapy, chemotherapy, radiotherapy, hormone therapy and targeted therapy of encephalomyelitis disseminate/multiple sclerosis (MS) and hepatitis A, B, C, D, E, F and G virus enter and targets liver cells”. J Proteomics Enzymol 6: 1.
  97. Heidari A (2017) “Transport therapeutic active targeting of human brain tumors enable anti-cancer nanodrugs delivery across the blood-brain barrier (BBB) to treat brain diseases using nanoparticles and nanocarriers under synchrotron radiation”. J Pharm Pharmaceutics 4: 1-5.
  98. Heidari A, Brown C (2017) “Combinatorial therapeutic approaches to DNA/RNA and benzylpenicillin (penicillin g), fluoxetine hydrochloride (prozac and sarafem), propofol (diprivan), acetylsalicylic acid (ASA) (aspirin), naproxen sodium (aleve and naprosyn) and dextromethamphetamine nanocapsules with surface conjugated DNA/RNA to targeted nano drugs for enhanced anti-cancer efficacy and targeted cancer therapy using nano drugs delivery systems”. Ann Adv Chem 1: 061-069.
  99. Heidari A (2016) “Vibrational spectroscopy of nucleic acids”. wahid ali khan (editor), “basic biochemistry”. Basic Biochemistry.
  100. Heidari A (2017) “High-resolution simulations of human brain cancer translational nano drugs delivery treatment process under synchrotron radiation”. J Transl Res 1: 1-3.
  101. Heidari A (2017) “Investigation of anti-cancer nano drugs’ effects’ trend on human pancreas cancer cells and tissues prevention, diagnosis and treatment process under synchrotron and x-ray radiations with the passage of time using mathematica”. Current Trends Anal Bioanal Chem 1: 36-41.
  102. Heidari A (2017) “Pros and cons controversy on molecular imaging and dynamics of double-standard dna/rna of human preserving stem cells-binding nano molecules with androgens/anabolic steroids (AAS) or testosterone derivatives through tracking of helium-4 nucleus (alpha particle) using synchrotron radiation”. Arch Biotechnol Biomed 1: 067-0100.
  103. Heidari A (2017) “Visualizing metabolic changes in probing human cancer cells and tissues metabolism using vivo 1h or proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self-organizing maps under synchrotron radiation”. SOJ Mater Sci Eng 5: 1-6.
  104. Heidari A (2017) “Cavity ring-down spectroscopy (CRDS), circular dichroism spectroscopy, cold vapour atomic fluorescence spectroscopy and correlation spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Enliven: Challenges Cancer Detect Ther 4: e001.
  105. Heidari A (2017) “Laser spectroscopy, laser-induced breakdown spectroscopy and laser-induced plasma spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Int J Hepatol Gastroenterol 3: 079-084.
  106. Heidari A (2017) “Time-resolved spectroscopy and time-stretch spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Enliven: Pharmacovigilance and Drug Safety 4: e001.
  107. Alireza Heidari A (2017) “Overview of the role of vitamins in reducing negative effect of decapeptyl (triptorelin acetate or pamoate salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of malignant prostate tumors into benign prostate tumors under synchrotron radiation”. Open J Anal Bioanal Chem 1: 021-026.
  108. Heidari A (2017) “Electron phenomenological spectroscopy, electron paramagnetic resonance (epr) spectroscopy and electron spin resonance (ESR) spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Austin J Anal Pharm Chem 4: 1091.
  109. Heidari A (2017) “Therapeutic nanomedicine different high-resolution experimental images and computational simulations for human brain cancer cells and tissues using nanocarriers deliver DNA/RNA to brain tumors under synchrotron radiation with the passage of time using mathematica and MATLAB”. Madridge J Nano Tech Sci 2: 77-83.
  110. Heidari A (2017) “A consensus and prospective study on restoring cadmium oxide (CDO) nanoparticles sensitivity in recurrent ovarian cancer by extending the cadmium oxide (CDO) nanoparticles-free interval using synchrotron radiation therapy as antibody-drug conjugate for the treatment of limited-stage small cell diverse epithelial cancers”. Cancer Clin Res Rep 1: e001.
  111. Heidari A (2017) “A novel and modern experimental imaging and spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under white synchrotron radiation”. Cancer Sci Res Open Access 4: 1-8.
  112. Heidari A (2017) “Different high-resolution simulations of medical, medicinal, clinical, pharmaceutical and therapeutics oncology of human breast cancer translational nano drugs delivery treatment process under synchrotron and x-ray radiations”. J Oral Cancer Res 1: 12-17.
  113. Heidari A (2017) “Vibrational Decihertz (dHz), Centihertz (cHz), Millihertz (mHz), Microhertz (μHz), Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz (yHz) imaging and spectroscopy comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation”. International Journal of Biomedicine 7: 335-340.
  114. Heidari A (2017) “Force spectroscopy and fluorescence spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. EC Cancer 2: 239-246.
  115. Heidari A (2017) “Photoacoustic spectroscopy, photoemission spectroscopy and photothermal spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. BAOJ Cancer Res Ther 3: 045-052.
  116. Heidari A (2017) “J-Spectroscopy, Exchange Spectroscopy (EXSY), nuclear overhauser effect spectroscopy (NOESY) and total correlation spectroscopy (TOCSY) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation”. EMS Eng Sci J 1: 006-013.
  117. Heidari A (2017) “Neutron spin echo spectroscopy and spin noise spectroscopy comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Int J Biopharm Sci 1: 103-107.
  118. Heidari A (2017) “Vibrational decahertz (daHz), hectohertz (hHz), kilohertz (kHz), megahertz (MHz), gigahertz (GHz), terahertz (THz), petahertz (PHz), exahertz (EHz), zettahertz (ZHz) and yottahertz (YHz) imaging and spectroscopy comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation”. Madridge J Anal Sci Instrum 2: 41-46.
  119. Heidari A (2018) “Two-dimensional infrared correlation spectroscopy, linear two-dimensional infrared spectroscopy and non-linear two-dimensional infrared spectroscopy comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation with the passage of time”. J Mater Sci Nanotechnol 6: 101.
  120. Heidari A (2018) “Fourier transform infrared (FTIR) spectroscopy, near-infrared spectroscopy (NIRS) and mid-infrared spectroscopy (MIRS) comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation with the passage of time”. Int J Nanotechnol Nanomed 3: 1-6.
  121. Heidari A (2018) “Infrared photo dissociation spectroscopy and infrared correlation table spectroscopy comparative study on malignant and benign human cancer cells and tissues under synchrotron radiation with the passage of time”. Austin Pharmacol Pharm 3: 1011.
  122. Heidari A (2017) “Novel and transcendental prevention, diagnosis and treatment strategies for investigation of interaction among human blood cancer cells, tissues, tumors and metastases with synchrotron radiation under anti-cancer nano drugs delivery efficacy using MATLAB modeling and simulation”. Madridge J Nov Drug Res 1: 18-24.
  123. Heidari A (2018) “Comparative study on malignant and benign human cancer cells and tissues with the passage of time under synchrotron radiation”. Open Access J Trans Med Res 2: 00026-00032.
  124. Gobato MR, Gobato R, Heidari A (2018) “Planting of Jaboticaba Trees for Landscape Repair of Degraded Area”. Landscape Architecture and Regional Planning 3: 1-9.