Stroke Could Be Better Predicted with Discovery of Biomarker

In recent days stroke is a leading cause of disability and death, researchers found that people who had higher level of four inflammatory biomarkers in their blood were at greater risk of stroke when compared with those with low levels. Future research could also investigate ways to prevent the stroke by lowering the levels of inflammatory biomarkers or by blocking their action.


Stroke is a condition which occurs when the flow of blood (Oxygen rich) to the brain is reduced, resulting the brain cell death. According to the studies done in the U.S. one of Heath organisation, 130,000 people were dying per year because of Stroke kills which is about 1 in every 20 deaths. Major risk factors like High Cholesterol, high Blood Pressure, Smoking and Age called the Framingham Stroke Risk Profile, improved the ability to predict who would develop a stroke. Present studies suggesting that by adding four biomarkers to an existing method of stroke assessments could improve the prediction capability.

Upto 33% of greater stroke risk with higher level of biomarkers, to support their findings researchers are analysed data from the Framingham Heart Study Offspring Cohort, which included 3,224 subjects of an average age of 61 years with no history of stroke. Blood samples were collected from the participants at study baseline and assessed the presence of inflammatory biomarkers. They observed that inflammatory biomarker plays a role in ischemic stroke, whereby a vessel supplying blood to the brain becomes blocked.

During the 9 years of follow-up, 98 participants are experienced with stroke; the researchers report shows that high level of four inflammatory biomarkers were associated with greater stroke risk.

  • ln-tumor necrosis factor receptor 2; a 33 percent increased stroke risk
  • Homocysteine; a 32 percent increased risk
  • In-C reactive protein; a 28 percent increased risk
  • Vascular endothelial growth factor; a 25 percent increased risk.

The mentioned findings are purely observational, so researchers are unable to achieve that high levels of these biomarkers cause stroke. Still, the researchers are encouraged by their findings, and they suggest that including the four biomarkers in the Framingham Stroke Risk Profile could better pinpoint patients who are likely to experience stroke.

Journal of Neurology and Psychology

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